| abstract |
FIELD: medicine. n SUBSTANCE: invention relates to compound of structural formula (1), which possesses inhibiting activity with respect to rotamase «FKBP12». In formula R 1 represents formulae or X represents -(CH 2 ) m -X 1 -(CH 2 ) n -; X 1 represents bond, -O-, -NR a C(=O)-, -C(=O)NR b -, -NR c S(=O) 2 - or -S(=O) 2 NR d -; R a , R b , R c and R d , each can be similar or different and represent hydrogen atom or C 1-6 alkyl group; m and n, each, can be similar or different and represent integer number 0-3; R 2 represents phenyl group, pyridyl group, pyridazyl group, pyrimidyl group or pyrazinyl group. Values of ring A radical and substituents of R 2 radical are disclosed in invention formula. Invention also relates to pharmaceutical preparation, which contains claimed compound, and to medication for prevention of treatment of alopecia. n EFFECT: increase of treatment efficiency. n 12 cl, 3 dwg, 1 tbl, 24 ex |