| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: claimed invention relates to compounds of formula where A 1 and R 1 , R 2 , R 3 , R 4 and R 5 are determined in invention formula, which are preferable inhibitors of cathepsin cycteinprotease, in particular cathepsin S or L cycteinprotease, which makes them useful as medications, especially for treatment of diabetes, atherosclerosis, aneurism of abdominal aorta, peripheral arterial disease or diabetic nephropathy. n EFFECT: invention relates to methods of obtaining claimed compounds, thereof-containing pharmaceutical composition and thereof application. n 24 cl, 1 tbl, 255 ex |