| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to organic chemistry, particularly to novel carboxamide compounds of formula and to pharmaceutically acceptable salts thereof, where R 1 is phenyl-C 1 -C 6 -alkyl, where the phenyl can be unsubstituted or substituted with 1 radical R 1c ; where R 1c is independently selected from halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, where the C 1 -C 6 alkyl groups can be partially or completely halogenated or can have 1, 2 or 3 substitutes R 1a , and -(CH 2 ) p -NR c6 R c7 , where p=0, 1, where R 1a is independently selected from NR a6 R a7 , R a6 is C 1 -C 6 -alkyl, R a7 is C 1 -C 6 -alkyl, or two radicals R a6 and R a7 , or R c6 and R c7 together with a N atom form a nitrogen-containing 6-member saturated heterocycle, which can optionally have 1 additional O heteroatom as a ring member, R 2 is phenyl, pyridyl, where the phenyl can be unsubstituted or can have 1 substitute R 2c ; where R 2c has one of the values given for R 1c ; R 3 is C 1 -C 6 -alkyl, C 3 -C 6 -alkenyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkyl-C 1 -C 2 -alkyl, where C 1 -C 6 alkyl, is unsubstituted or has 1 substitute R xa , where R xa has one of the values given for R 1a ; R 5 is a halogen or C 1 -C 2 -alkyl, where m equals 0 or 1; n equals 0. The invention also relates to specific compounds and a pharmaceutical composition based on the compound of formula (I). n EFFECT: obtaining novel carboxamide compounds which are useful as calpain inhibitors (calcium-dependent cysteine proteases). n 27 cl, 4 tbl, 34 ex |