| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a compound of formula VIla: n n n n where: R 84 is selected from a group consisting of hydrogen, C 1-6 alkoxy, and -Cl; R 92 , R 94 , R 95 and R 96 are independently selected from a group consisting of hydrogen, halogen and fluoro-substituted C 1-6 alkyl; R 99 is selected from a group consisting of C 1-6 alkyl, optionally substituted phenyl, thiophene and -NR 79 R 80 , where the phenyl substitutes are selected from halogen and fluoro-substituted C 1-6 alkyl; and R 79 and R 80 are independently hydrogen or C 1-6 alkyl, or R 79 and R 80 are combined with a nitrogen atom with which they are bonded to form a 5-7-member heterocycloalkyl in which 1-3 carbon atoms are substituted with O, S or N heteroatoms. n EFFECT: said compounds are active with respect to protein kinase. n 25 cl, 2 tbl, 59 ex |