abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to specific derivatives of pyrrolidine-2-carboxamides specified in point 1 of the patent claim, and their pharmaceutically acceptable salts. The invention also refers to a pharmaceutical composition inhibiting the p53 and MDM2 reaction and to using the above compounds for treating cancer. n EFFECT: derivatives of pyrrolidine-2-carboxamide as p53 and MDM2 protein reaction inhibitors applicable for treating cancer. n 11 cl, 475 ex |