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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7076
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filingDate 2014-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d79bf29ddd2b5f672998a5e24fcbf1f3
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publicationDate 2015-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2563796-C1
titleOfInvention Method of treating ischemic hepatic injuries
abstract FIELD: medicine. n SUBSTANCE: hepatectomy using an intraoperative extracorporeal temporal portacaval shunt is performed in an experimental animal. On the day of the surgical intervention, the slow intravenous bolus administration of Heptral, the solution for injections, follows 1.5 hours prior to the surgical intervention in a dose of 2 mg/kg, 2 hours after the first administration - in a dose of 6 mg/kg and 8 hours after the first administration - in a dose of 4 mg/kg. What is also required is the slow intravenous bolus administration of Clarithromycin in NaCl solution 0.5 in a dose of 3 mg/kg three times a day at 7 00 , 15 00 and 23 00 . The postoperative period involves administering Heptral two times a day - at 9 00 in a dose of 7 mg/kg, at 16 00 in a dose of 5 mg/kg; Clarithromycin - three times a day at 7 00 , 15 00 and 23 00 in a dose of 3 mg/kg. The total length of administering Heptral and Clarithromycin is 10 days. n EFFECT: method provides treating, correcting and preventing a surgical infection, ischemic and reperfusion hepatic injuries, lengthening safe periods of liver exsanguinations and avoiding major haemorrhages potentially accompanying the hepatic surgical intervention. n 3 ex, 5 tbl
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