| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to 4-pyridinone compounds of formula I: , where Y represents CN, C 2-6 -alkinyl, (CH 2 ) n C 5-10 -heterocyclyl, (CH 2 ) n C 6-10 -aryl, with said alkinyl, heterocyclyl and aryl being substituted with 1-3 groups R a ; X, X 1 and R 1 independently represent hydrogen, halogen, CN, C 1-6 -alkyl, with said alkyl being optionally substituted with 1-3 groups R a ; R 2 represents H, OH, C 1-6 -alkyl, (CH 2 ) n C 3-10 -cycloalkyl, (CH 2 ) n C 5-10 -heterocyclyl, (CH 2 ) n C 6-10 -aryl, with said aryl and heterocyclyl being optionally substituted with 1-3 groups R a ; R a represents C 1-6 -alkyl, halogen, CF 3 , OCF 3 , NR 2 C(O)R 2 , C(O)N(R 2 ) 2 , C(O)R 2 , CN, NHSO 2 R 2 , OR 2 , (CH 2 ) n C 5-10 -heterocyclyl, (CH 2 ) n C 6-10 -aryl, with said alkyl, heterocyclyl and aryl being optionally substituted with 1-3 groups R b ; R b represents halogen; and n represents integer number from 0 to 2, which are catechol-O-methyltransferase (COMT) inhibitors. n EFFECT: obtaining 4-pyridinone compounds. n 14 cl, 1 tbl, 16 ex |