| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to compounds of formula possessing the neurokinin-3 (NK-3) receptor antagonist, a based therapeutic agent, using them and a method of treating with using them. In general formula (I), R 1 represents hydrogen, halogen, lower alkyl; n represents 1, 2, if n represents 2; R 2 represents hydrogen or methyl; R3 represents (CH2) r -C(O)NH 2 , wherein r represents 1 or 2, or represents a non-aromatic heterocyclic group , wherein X represents N or CH; Y represents -C(R)(R 7 )-; -N(R 7 )-, -S(O) 2 or O; R 6 represents hydrogen, di-lower alkyl or =O; o and m can be 0, 1 or 2 independently; p represents 0, 1 or 2. n EFFECT: compounds of formula (I) can find application in treating depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD). n 22 cl, 1 tbl, 321 ex |