| abstract |
FIELD: medicine. n SUBSTANCE: invention refers to medicine, nanotechnologies, particularly to increasing the probing contrast and depth in forming THz images of cancers and skin pathologies with the use of nanoparticles and laser heating. The method involves introducing plasma-resonant composite nanoparticles into a probed biological tissue and exposing the probed biological tissue to a laser beam at a wave length of 700-900 nm agreed with the peak absorption of the nanoparticles. The probed biological tissue is exposed to a pulse sequence of THz electromagnetic waves, measuring a reflection coefficient of the THz electromagnetic waves with the spatial scanning of the probed biological tissue. The exposure is preceded by local applications of a biologically compatible agent in the liquid form possessing hyperosmotic properties: glycerol, or polyethylene glycol, or propylene glycol, or an alcoholic solution of glucose or fructose. The laser beam exposure is performed in the mode of a femtosecond pulse sequence at a pulse repetition cycle of no more than 10 ns synchronised with the THz electromagnetic wave pulse sequences so as to feed both pulses into the probed region simultaneously. A part of the laser beam for exposing the probed biological tissue can be used to generate the THz electromagnetic wave pulse sequence. n EFFECT: method provides the higher probing contrast and depth of the biological objects with a spatial resolution of at least 100 mcm. n 2 cl, 3 dwg |