abstract |
FIELD: medicine. n SUBSTANCE: present invention refers to immunology. There are also disclosed: a recovered nucleic acid coding an antibody or its antigen-binding fragment, an expression vector, a host cell, a method for producing the antibody or its antigen-binding fragment according to the invention, compositions containing the antibody or antigen-binding antibody fragment according to the invention, using the antibody or antigen-binding fragment according to the invention in producing a medicinal agent for reducing PGE 2 activity in a subject individual and for treating the individual, as well as a method for detecting PGE 2 or its fragment in a test sample by immunoassay. The present invention can find further application in therapy and diagnosis of the diseases related to PGE 2 hyperactivity or overexpression. n EFFECT: there are presented the antibody and its antigen-binding fragment binding prostaglandin E 2 (PGE 2 ) and characterised by CDR sequences. n 25 cl, 9 dwg, 21 tbl, 4 ex |