http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2558952-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2e54e680bae7ea466df38059b205d47 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-14 |
| filingDate | 2012-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44b3ce9161db0682d11c5a3c1912c831 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a9c180eda67ee56542035d2d1f584f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_241c59e1ea6281b8d2f028d33088d67f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d369f691999fe9ccd2765da945efc529 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_602555ebae77cc931488ec8d690dda1a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebab988e915f26d5a9fe9a4c7528ccc1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_002fea6e5d36789dd3f0ac746d8acb3f |
| publicationDate | 2015-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2558952-C2 |
| titleOfInvention | (r)- and (s)-isomers of 3-methylspermidine |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to novel trihydrochlorides of (R)- and (S)-isomers of 1,8-diamino-3-methyl-4-azaoctane (3-methylspermidine), corresponding to structural formulae given below and to a method for production thereof. Said compounds can be used in vitro and in vivo to investigate individual cell functions of easily interconvertible and partially interchangeable spermine and spermidine, which are vital for tumour cells and pathogenic trypanosomatids. The (R)-isomer of 3-methylspermidine trihydrochloride is the first metabolically stable functionally active spermidine mimetic. n . A method of producing said isomers includes alkylating salts of (R)- and (S)-isomers of N 1 -protected 1,3-diaminobutane sulphamide with N-protected 1-amino-4-butylhalides, followed by successive removal of protective groups and treatment of the obtained residue with hydrochloric acid solution. The alkylating agent used can be N-(phthaloyl)-1-amino-4-butylhalides in aprotic polar solvents or N-(4-iodobutyl)phthalimide in dimethyl formamide in the presence of calcium carbonate. Removal of the phthalyl protection is normally carried out with hydrazine hydrate in alcohol. Removal of benzyloxycarbonyl groups is normally carried out by catalytic hydrogenation over Pd-black at atmospheric pressure in a mixture of methanol and acetic acid. n EFFECT: converting the obtained triacetates of R)- and (S)-isomers of 1,8-diamino-3-methyl-4-azaoctane into tetrahydrochlorides is carried out with aqueous hydrochloric acid solution. n 7 cl, 5 dwg, 5 ex |
| priorityDate | 2012-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 187.