abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to the field of organic chemistry, namely to a method of obtaining solid forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide (compound 1 of form A, A-HCl, B and B-HCl). Methods of obtaining intermediate compounds 2 and 3-HCl are also described. n EFFECT: methods for obtaining compound 1 in the solid form, useful as CFTR modulators have been elaborated , . n 21 cl, 22 dwg, 11 tbl, 8 ex |