http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2553476-C2

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filingDate 2008-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2015-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2553476-C2
titleOfInvention Method of synthesising e1-activating enzyme inhibitors
abstract FIELD: chemistry. n SUBSTANCE: invention relates to a method of obtaining a formula compound. The method includes a stage of binding a formula compound with a formula compound in the presence of a base with the formation of the formula (I) compound. In formula (I) stereochemical configurations in the positions, marked with asterisks, are relative; R b represents hydrogen; R 00 represents a C 1-10 aliphatic group or a C 6-14 aryl group, including one-three rings; R d , R e , R e' , R f , R h , R h' , R k represent hydrogen; R g represents chlorine, fluorine, iodine or bromine; R m represents a protective hydroxyl group; values of radicals R a , R*, R c are given in the invention formula. In formulas (II) and (III) R a , R b , R c , R d , R e , R e' , R f , R g , R h , R h' , R j , R k and R m are such as determined in formula (I) and R 1 represents -CH 2 CHO. The invention also relates to methods of obtaining compounds of formulae (V), (VI), (VId) and to a compound of the structural formula (IIa). Structural formulae of compounds (V), (VI), (VId), (IIa) are given in the invention formula. n EFFECT: method makes it possible to carry out synthesis in a regioselective way and use the obtained product without purification. n 15 cl, 1 tbl, 26 ex
priorityDate 2007-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 49.