http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2551238-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a252cc5b90d78e321f08da5e8168741d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate | 2013-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d06b2500f147fbfcca1c8f9ebca8378 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a3401411f15b240c8b49b1b5c9f13e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_517ffa8793f29c4330338d1b9c94df43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c89509c4ab089ebc8e3fc26fe9868464 |
| publicationDate | 2015-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2551238-C2 |
| titleOfInvention | Method of inducing apoptosis of malignant tumour cells of colorectal cancer and means for its realisation |
| abstract | FIELD: medicine. n SUBSTANCE: invention relates to biochemistry. Described is method of inducing apoptosis of malignant tumour cells of colorectal cancer. Inhibition of function of genes from group: c-IAP2, Livin and MCM4 is carried out. For this purpose applied are medications of small interfering miRNA-oligonucleotides from group UGUGGACAAAGUCUCUUCCdTdT; CCUGUGGGUAAGAAGAUGAGdTdT; UUCUCUCUCCUCUUCCCUUAdTdT. Simultaneous inhibition of functions of genes from group: c-IAP2, Livin and MCM4, in one of gene combination: Livin and MCM4; c-IAP2 and MCM4; c-IAP2 and Livin is performed. In particular, simultaneous inhibition of functions of two genes from group: c-IAP2, Livin and MCM4 is carried out. Disclosed is means for said method realisatio, which contains oxaliplatin and combination of complementary to mRNA in cells of malignant tumour shRNA-oligonucleotides in form of short loop shRNA. n EFFECT: invention makes it possible to optimise and activate apoptotic influences of platinum-containing medication on cells of colorectal cancer tumour, which ensures essential apoptotic death of cancer cells with dose of medication, fundamentally lower than the standard one. n 7 cl, 3 dwg, 1 tbl |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2644675-C1 |
| priorityDate | 2013-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 123.