http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2550694-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1a25e67d6cd970eabc0a9bbc58436409 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 |
| filingDate | 2011-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f10f156c7b3db21a400bc6c76495df5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8cbd50a114cdd1a4916263ca113646b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9435f96f500d57571c1bcd9b007ad56d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12f5ef50b80e69fc862415cdccb1021e |
| publicationDate | 2015-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2550694-C2 |
| titleOfInvention | Synthesis of substituted pyrazoline carboxamidine derivatives |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to a method of producing pyrazoline carboxamidine derivatives of formula . Said compounds are known as powerful 5-HT 6 antagonists. The disclosed method comprises reacting a corresponding substituted 4,5-dihydro-(1H)-pyrazole or an isomer thereof with isothiocyanate R 6 -N=C=S to obtain an amide of substituted 4,5-dihydro-(1H)-pyrazole-1-carbothioic acid or tautomeric substituted 4,5-dihydro-(1H)-pyrazole-1-carboxymidothioic acid . The obtained intermediate compounds are reacted with a corresponding alkylating agent to obtain an intermediate S-alkylated compound . Said intermediate compound is reacted with a sulphonamide derivative R 7 SO 2 NH 2 and the target compound of formula (I) is separated from the reaction mixture. The invention also relates to novel intermediate products (III a ), (III b ) and (IV). Symbols given in the formulae have values given in the description. n EFFECT: providing an alternative method which improves atom efficiency of synthesis of desired compounds with higher output compared to existing methods for synthesis of said compounds. n 8 cl, 1 tbl, 3 ex |
| priorityDate | 2010-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 216.