abstract |
FIELD: biotechnology. n SUBSTANCE: humanised monoclonal antibody against TNF and its application are described. n EFFECT: invention enables to reduce significantly the immunogenicity of murine antibody while maintaining the ability of the antibody to recognise the antigen as compared with the conservative chimeric murine antibody, increased antibody safety in clinical applications. n 11 cl, 3 dwg, 5 tbl, 16 ex |