| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to organic chemistry, namely to pyrazine derivatives of formula I, as well as to their enanthiomers, diastereomers and pharmaceutically acceptable salts, wherein R 1 is specified in a group consisting of ii) pyridinyl optionally having one substitute specified in a group consisting of C 1-4 alkoxy and cyano; and iii) pyrimidin-5-yl; or R 1 optionally represents methoxymethyl, when Y represents ethinyl; Y represents ethinyl or a bond; R 2 represents phenyl, benzofuranyl, 2,3-dihydrobenzofuranyl, benzo[1,3]dioxol-5-yl, indolyl or pyridinyl substituted by methyl, phenyl has one to two substitutes independently specified in a group consisting of C 1-4 alkyl, C 1-4 alkoxy, fluorine, chlorine, cyano, cyanomethyl, difluoromethyl, trifluoromethyl and hydroxy; or R 2 represents phenyl having one C 1-4 alkylcarbonylamino or 1H-imidazol-1-yl substitute; X represents O or CH 2 ; L is absent, and R 3 represents 4-aminocyclohexyl, or L represents methylene, while R 3 is specified in a group consisting of i) pyrrolidin-2-yl; ii) 1-aminoeth-1-yl; and iii) 1-aminocyclopent-1-yl; or R 3 is combined into one cycle with L nitrogen atom to which L is attached to form piperazinyl. Besides, the invention refers to specific compounds, a pharmaceutical compound based on a compound of formula I, a method of treating pain and some neurodegenerative diseases. n EFFECT: there are produced new pyrazine derivative effective in treating pain and some neurodegenerative diseases. n 21 cl, 3 tbl, 13 ex |