http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2543338-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9a8804e9e5c36ac4a02788e579f021a6 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16 |
| filingDate | 2013-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0394b6caea360fa44551b3d48ed80845 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e09c0ffd80ffc9682249027a53d425e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72e0957a3f768f09b8ef701038a8e216 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd131d97f5d10d612f176da44ad82aaf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4805e2542072ec363dc1a5f03a5066b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_952b42c6370cca5cd2d92822bbdd3bd3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9a3b900ac7bf77791f560f976966c7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05b370200ef3f03c4572bb8ceee4f1f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2648061d088f9fd2fda0ca5b2439f671 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12f62ed0fcadbdb96f0c6615cdf6712c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd31bebf2713813e4b985711e19f9085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aac477ac375202aa4dfc08b9dc9e0a88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9b6f7cf7d8f31b01c5734efd30626a8 |
| publicationDate | 2015-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2543338-C1 |
| titleOfInvention | Medicated product for smallpox virus and method for producing and using it |
| abstract | FIELD: medicine.SUBSTANCE: invention refers to a medicated product based on a chemical compound of 7-[N'-(4-trifluoromethylbenzoyl)-hydrazinocarbonyl]-tricyclo[3.2.2.0]non-8-ene-6-carboxylic acid (NIOH-14, N.N. Vorozhtsov Novosibirsk Institute Of Organic Chemistry) in a dose of 4 to 60 mg/kg of body weight, possessing the anti-smallpox virus activity, as well as a method for producing and using for the smallpox virus for preventing and treating mammals involving oral administration once a day in a dose range from 4 to 60 mg/kg of the mammalian body weight. A method for producing the medicated product possessing the anti-smallpox virus activity involves diluting and performing a reaction of 4-trifluorobenzoic acid hydrazide and 3,3a,4,4a,5,5a,6.6a-octahydro-1,3-dioxo-4,6-etheno-cycloprop[f]-furane in a molar ratio of 1:1 in a solvent and mixing the produced suspension until producing sediments which are removed from the solution, filtered and dried to produce an end product that is a chemical compound of 7-[N'-(4-trifluoromethylbenzoyl)-hydrazinocarbonyl]-tricyclo[3.2.2.0]non-8-ene-6-carboxylic acid (NIOH-14, N.N. Vorozhtsov Novosibirsk Institute Of Organic Chemistry). The solvent is ethyl or isopropyl alcohol; preparing the suspensions, separating and filtering the sediments are performed at a temperature of +2-10°C, while a dry product yield makes 96.0%.EFFECT: invention provides the less toxic preparation of the medicated product, possessing the high anti-smallpox virus activity.4 cl, 4 tbl, 4 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2716709-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2748249-C1 |
| priorityDate | 2013-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.