http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2541545-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_85acec314572629be23b8257de039e3b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-02 |
| filingDate | 2013-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_582aab593e2db781e36e01bfb678971f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad1215aa7487e1a92a88d04e0426afbf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db5f42d641ae57fedc4d822844049238 |
| publicationDate | 2015-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2541545-C2 |
| titleOfInvention | Method of obtaining hydrochlorides of adamantane amines |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to method of obtaining hydrochlorides of adamantane amines, including 1-aminoadamantane hydrochlorides or 3,5-dimethyl-1-aminoadamantane, which are pharmaceutical substance of medications "Midantan" and "AcatinpolMemantine". Method consists in oxidation of cage hydrocarbon, selected from adamantane or methyl-substituted adamantanes, with fuming nitric acid in molar ratio 1:7-13.3 respectively, in presence of glacial acetic acid in molar ratio 1:1-3.25 counted per initial substrate at room temperature. After that, acetone cyanohydrin is added in molar ratio 1:3.5-10.4 and water in molar ratio 1:75.1-102.9 counted per initial substrate, with further heating with boiling of reaction mass for 1-3 h, neutralisation of obtained reaction mass and addition of hydrochloric acid. n EFFECT: method in accordance with invention is simpler in comparison with previously known methods, because it does not require application of hard-to-obtain reagents, eliminates stage of thermal decomposition of intermediate product, makes it possible to increase environmental friendliness, reduce amount of wastewater and is more fire- and explosion-safe. n 12 ex |
| priorityDate | 2013-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.