http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2540332-C2
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-69 |
filingDate | 2010-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2015-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c544206ccc3b92f028aadc9326e307b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a848a86d341e0ba3561fd2eb1dbd0ec5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6c9ce08d84d284381a3ffe268bb1628 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63edb4c1ca91e0a96e677eba648eaa3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce151e4c3d5b728f4f4388444a461343 |
publicationDate | 2015-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | RU-2540332-C2 |
titleOfInvention | Bicyclic nitrogen-containing heterocyclic compounds, useful in treatment of hepatitis c |
abstract | FIELD: chemistry.SUBSTANCE: invention relates to field of organic chemistry, namely to novel heterocyclic compounds of general formula(I) or to their pharmaceutically acceptable salts, where Xstands for N and X, Xand Xstand for CR; or Xand Xstand for N and Xand Xstand for CR; or X, Xand Xstand for CR, and Xstands for N; or X, X, Xand Xstand for CR; Rstands for (a) heteroaryl radical, selected from the group, including pyridinyl, 2-oxo-1,2-dihydropyridin-3-yl, 2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl, said heteroaryl optionally contains as substituents halogen, C-C-alkyl, C-C-hydroxyalkyl, C-C-alkoxy-C-C-alkyl, C-C-alkoxygroup, or (b) heterocyclic radical, selected from the group, including 2-oxotetrahydropyrimidin-1-yl, 2,6-dioxotetrahydropyrimidin-1-yl, 2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl and 2,4-dioxotetrahydropyrimidin-1-yl; Rstands for hydrogen or C-C-alkoxygroup; Rstands for (a) phenyl, (b) pyridine, where said phenyl or said pyridine independently optionally contain 1-3 substituents, selected from the group, including halogen, (CH)NRR, or (c) NRR, (d) hydrogen, (e) halogen; Rand Rtogether with nitrogen atom, which they are bound to, form cyclic amine, containing from 3 to 5 carbon atoms, independently substituted with group (CH)NRR; Rand Rindependently stand for hydrogen, SOR, where Rstands for C-C-alkyl; Rand Rindependently stand for hydrogen, SOR, where Rstands for C-C-alkyl; Rstands for CF, CHCFor CRRR, where (i) R, Rand Rare independently selected from the group, including C-C-alkyl, CD; or (ii) taken together Rand Rform C-C-alkylene and Rstands for cyanogroup or C-C-fluoroalkyl; Rin each case independently stands for hydrogen, halogen, C-C-alkoxygroup or C-C-alkyl; n in each case independently equals 0-3. Invention also related to method of treating infection with hepatitis C virus, method of inhibiting HCV replication, application of formula (I) compound and based on it pharmaceutical composition.EFFECT: novel heterocyclic compounds of formula (I), possessing useful biological activity are obtained.24 cl, 3 tbl, 43 ex |
priorityDate | 2009-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 858.