| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: present invention presents formulations providing the effective delivery of methylnaltrexone compositions. A pharmaceutical composition according to the invention contains an effective amount of methylnaltrexone, calcium ethylenediaminotetraacetic acid (EDTA) or calcium-disodium salt of EDTA and hydrochloride glycine in an aqueous solution. The above solution has pH from approximately 3 to approximately 4. What is also described is a method for preparing the formulation of methylnaltrexone. n EFFECT: composition is characterised by long-storage and severity stability; it ensures preventing, treating, delaying, relieving or reducing a severity of side effects accompanying the administration of analgesic opioids. n 30 cl, 4 dwg, 20 tbl, 14 ex |