| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention relates to field of pharmaceutics and represents pharmaceutical depot, made for introduction by intra-articular injection into joint of subject, suffering from osteoarthritis, which contains microparticles or nanoparticles, composed of N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-3-fluoro-4-[pyridin-2-ylmethoxy)benzamide or its pharmaceutically acceptable salt and biodegradable copolymer lactic acid-glycolic acid. n EFFECT: invention provides controlled release of active agent and long action without toxic side effects. n 13 cl, 5 ex, 3 tbl, 9 dwg |