http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2533825-C2
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da72506020ac9aacffbfb73ef397db24 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 |
filingDate | 2010-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2014-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fd45531179817b9059d60a8a541ecb6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6266158f8bd272ea99299e14b04ad6eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6c1cd55ca2ecb64bfab4a574e546aed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2f3ee0620446b8e064b0d3714dff78f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97d8643a3a55efc8660ef38147cabe58 |
publicationDate | 2014-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | RU-2533825-C2 |
titleOfInvention | BENZIMIDAZOLE AND IMIDAZO[4,5-c]PYRIDINE DERIVATIVES AS HEDGEHOG PATHWAY ANTAGONIST |
abstract | FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to organic chemistry, namely to a heterocyclic compound of formula Iand its pharmaceutically acceptable salt, wherein if a chemical valency permits, i represents 1 or 2, Rrepresents H; a linear (C-C) alkyl group, Rrepresents H, Cl or F, X represents either N, or CR, Rrepresents H; halogen; a linear (C-C) alkyl or (C-C) alkoxyl group, Y representsZ represents O or NRx, Rx represents H or a linear or branched (C-C) alkyl, k is equal to 2, 3 or 4, n and p independently represents 2, and a sum of n+p cannot exceed 4, T represents H or a linear (C-C) alkyl group; T? represents a linear C-Calkyl chain substituted by either (C-C)-dialkylaminogroup, or a 5-6-merous saturated heterocycle containing one nitrogen atom and optionally containing the second heteroatom specified in O, such a heterocyclic ring is optionally substituted by a (C-C) alkyl chain at nitrogen atoms; or a 5-merous saturated heterocycle containing one nitrogen atom, such a heterocyclic ring is optionally substituted by a (C-C) alkyl chain at nitrogen atoms; r represents zero, 1; R? represents di(C-C)alkylamino, (C-C)alkoxy; except for the compounds specified in the clause. The invention also refers to a pharmaceutical composition based on the compound of formula (I), using the compound of formula (I) and to a method of treating diseases, in which the hedgehog signalling pathway modulation is effective.EFFECT: there are prepared new heterocyclic compounds possessing t effective biological properties.20 cl, 193 ex |
priorityDate | 2009-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 367.