| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to immunology and biotechnology. There are presented variants of antagonist antibodies binding to the interleukin-7 receptor (IL-7R). There are described: variants of nucleic acids coding the antibodies; a host cell recombinant producing the antibody; a pharmaceutical composition inhibiting the human IL-7R function, and methods of treating and/or preventing: an autoimmune disease specified in the group of type 1 diabetes, lupus, multiple sclerosis, rheumatoid arthritis; type 2 diabetes or graft-versus-host disease based on using the antibody. n EFFECT: invention provides the antagonist anti-IL-7R antibodies that can find application in medicine. n 17 cl, 15 dwg, 8 tbl, 13 ex |