http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2532842-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27c63baa76ad8126ba59bd592a30f614 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate | 2013-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95286c711c124b55fc5bef51f6fc1e68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34bf2ae30d96851ceb883e20f7f474bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a838116a9385a6683c192c2346a3dbe3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c017b03c3460a43ea57f482473a4ed2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26ec5c912ef4b41870045906f8274b59 |
| publicationDate | 2014-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2532842-C1 |
| titleOfInvention | Nucleic acid having activity of short interfering rna, vector containing this nucleic acid coupled operably with sequences of transcription regulation, and method of their application for inhibition of cell proliferation of human pancreatic adenocarcinoma |
| abstract | FIELD: biotechnology. n SUBSTANCE: invention relates to molecular biology, in particular to short interfering RNA (siRNA), and can be used in antitumor therapy. On the basis of genome analysis the sequences of siRNA against the human gene HIF1A with SEQ ID NO:1-2 are designed, siRNA against the human gene HSP8A with SEQ ID NO:3-4, siRNA against the human gene APEX1 with SEQ ID NO:5-6, and siRNA against the human gene CCND3 with SEQ ID NO:7-8, associated with cell proliferation of human pancreatic adenocarcinoma. Using the obtained siRNA, including as part of a lentiviral vector, results in suppression of cell proliferation of human pancreatic adenocarcinoma and tumor destruction. The invention enables to achieve the level of suppression of proliferation up to 65% using siRNA to genes HIF1A and HSP8A associated with stress and responsible for the major proliferative (CCND3) and reparative (APEX-1) ways of cell division. n EFFECT: improving level of suppression of proliferation. n 3 cl, 10 dwg, 2 ex |
| priorityDate | 2013-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 213.