| abstract |
FIELD: chemistry.SUBSTANCE: in general formula (I) Y is -CHR-CHR-CHR-; each of R, Rand Ris independently selected from a group consisting of hydrogen and C-C-alkyl; each of R, R, R, Rand Ris independently selected from a group consisting of hydrogen and unsubstituted C-C-alkyl; Ris selected from NRR; A is a radical (a), W is NR; Ris hydrogen; Ris hydrogen; each dotted line denotes an optional additional bond and one additional bond exists between carbon atoms to which Rand Rare bonded; one additional bond exists between carbon atoms to which Rand Rare bonded, and one additional bond exists between carbon atoms to which Rand Rare bonded; Ris a substituted or unsubstituted C-C-alkenyl, wherein the optional substitutes are selected from a group consisting of a halogen and OR', where each R? is hydrogen, silyl ethers as a protective group or CONR"R", where each R? is independently selected form hydrogen and C-C-alkyl; each of R, Rand Rare independently selected from a group consisting of hydrogen and OR; Ris hydrogen; and Ris an unsubstituted C-C-alkyl.EFFECT: high cytotoxic and cytostatic activity.21 cl, 1 tbl, 24 ex(a) |