http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2528046-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b968650429087c8657f95ea52c27e77f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate | 2005-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76ec352f9aa71dceb0e37dddda0307ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c89bfed0917adbdb74886cc02817a4b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a53c0ac6a99d010840ec3e28f39f36d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_392a559aa0670f2a9313380511946a60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_303bba52ff22a01414179d3f9378965a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5159b107296d5d7441fb84759a3a9d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee1b8b5628ee874004e19c6498b7bd3c |
| publicationDate | 2014-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2528046-C2 |
| titleOfInvention | Modulators of atp-binding cartridge transporters |
| abstract | FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to a compound of formula (VA-1), wherein WR W2 and WR W4 are independently specified in a hydrogen atom, -CN, -CF 3 , halogen, linear or branched (C 1 -C 6 )alkyl, a 3-12-merous cycloaliphatic group or phenyl, wherein WR W2 and WR W4 are independently and optionally substituted by up to three substitutes specified in -OR′, -CF 3 , -OCF 3 , -SR′, -S(O)R′, -SO 2 R′, halogen, -CN, -COOR′, -(CH 2 )OR′, -CH 2 CN, phenyl, phenoxy group, -N(R′)(R′), -NR′C(O)OR′, -NR′C(O)R′, -(CH 2 )N(R′)(R′); WR W5 is specified in a group consisting of a hydrogen atom, -CN, -CHF 2 , -N(R′) 2 , -NHC(O)R′, -NHC(O)OR′, -NHSO 2 R′, -OR′, -CH 2 OH, -CH 2 N(R′) 2 , -C(O)OR′, -SO 2 NHR′, -SO 2 N(R′) 2 or -CH 2 NHC(O)OR′; X means a bond; R x means the hydrogen atom; R′ is independently specified in the hydrogen atom, (C 1 -C 8 )aliphatic group, (C 3 -C 8 )cycloalkyl or phenyl. Also, the invention refers to a pharmaceutical composition possessing the properties of modulators of ATP-binding cartridge (ABC) transporters and containing the compound of formula , and to a method of treating or relieving a severity in a patient, wherein the above disease is specified in mucoviscidosis, hereditary emphysema, chronic obstructive pulmonary disease (COPD) or dry eye disease. n EFFECT: compound of formula (VA-1) as the modulators of the ATP-binding cartridge (ABC) transporters. n 24 cl, 14 tbl, 83 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2705577-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE47451-E |
| priorityDate | 2004-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 3076.