| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to 2,5 substituted arylsulphonamides of formula (Ia) or to their pharmaceutically acceptable salts, solvates, hydrates, stereoisomers or tautomers, where X represents S, SO or SO 2 ; Y and Z represents (i) Y represents NR 5 ; and Z represents =O, CO 2 R 6 or C 1-6 alkyl; or (ii) Y represents CH 2 , CHF, CHCH 3 , O, S or SO 2 ; and Z represents hydrogen or C 1-6 alkyl; R 1 and R 2 each independently represents halogen, C 1-6 alkyl or C 1-6 halogenalkyl; R 3 represents CN or NO 2 ; R 4 represents hydrogen or C 1-6 alkyl; R 5 represents hydrogen or C 1-6 alkyl; and R 6 represents hydrogen or C 1-6 alkyl. Invention also relates to compounds of formula (I) and (II), values of radicals of which are given in the invention formula, specific compounds, pharmaceutical composition based on compound of formula n , n and n , n method of modulating CCR3 activity. n EFFECT: obtained are novel compounds, possessing useful biological properties. n 18 cl, 1 tbl, 3 ex |