http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2524612-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51b404080d6dbcf852581390ba4bcd35 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-295 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-17 |
| filingDate | 2011-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b2a54406f5a00e9b8c501086b86c85e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f635c47cb25c1f55da13d23e5644bcd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1370ec6b4a36d1318175278f3fcfbfbc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b429bd25bddcfe76a1f58a500e9eee3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3297511ff7ae77a38ade1faef25c0c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13ffd9ba970bc450d891885095aac057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b1931fc26a451b8b2d5d535d50e69a2 |
| publicationDate | 2014-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2524612-C2 |
| titleOfInvention | Method of treating radiation, chemical and/or biological damage to organism and method of obtaining globulins for treatment of radiation, chemical and/or biological damage to organism |
| abstract | FIELD: medicine. n SUBSTANCE: group of inventions relates to veterinary and medicine, in particular to obtaining and application of biopreparations for immunotherapy of ecopathologies. The group of inventions includes obtaining a protein antigen from a mixture of anatoxins from three enteropathogenic virulent strains of a pathogen of escherichiosis of calves E.coli No. 378, 379, 380 by their growing on Hottinger medium with further addition of 0.4-0.5% formalin, following thermostating for 10-12 days and cooling the mixture of anatoxins with a sterile solution of aluminium hydroxide, after that obtaining radioantigen from E.coli "PL-6" by growing cultures on a meat infusion agar with further washing away a biomass by a physiological solution and irradiation of the obtained suspension with a concentration of 1.2·10 10 m.c./cm 3 on a gamma-installation in a dose of 140-150 Gr with following thermostating and extraction of radiotoxin with 70% acidified with 0.05% hydrochloric acid to pH 5.5 ethanol, following evaporation of the exractant to the initial volume, after that, obtaining protein-cadmium radioantigen first by preliminary dechlorination of cadmium chloride, obtaining cadmium hydroxide, addition into the obtained 2.7% solution of the antigen of 0.77% solution of cadmium hydroxide in a ratio of 1:1 with following thermostating at a temperature of 37°C for 30 minutes, evaporation and dissolution of the residue to 12.8% concentration, further obtaining protein-cadmium radioantigen by an addition of 1.2% solution of a mixture of three anatoxins of E.coli and 12.8% solution of cadmium radioantigen in a ratio of 1:9, conjugation of components at room temperature for 8-10 hours, standardisation by a dry substance to 10% concentration and pouring into vials, and storage at a temperature of 4-6°C. The group of inventions also relates to a method of treating radiation, chemical and/or bacteriological damage to an organism by introduction of 10% solution of complex protein-cadmium radioantigen. n EFFECT: application of the group of inventions is effective in treatment of radiation, chemical and/or biological damage. n 4 cl, 6 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2683650-C1 |
| priorityDate | 2011-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.