| abstract |
FIELD: medicine. n SUBSTANCE: invention refers to a visualising agent for visualisation of cell oxidative stress in vivo and a precursor compound for a synthesis of the visualising agent. The agent contains a tagged cystine compound having a structure I: wherein one of R and R' contains a tag specified in a fluorescent tag representing Bodipy, or a radioactive tracer specified in 11 C, 13 N, 15 O, 17 F, 18 F, 75 Br, 76 Br, 124 I, 123 I, 131 I and 77 Br, and the other of R and R' represents hydrogen. Also, the invention refers to a method for visualising a biological sample having a cystine/glutamate transporter with the method involving administering the above visualising agent into the above biological sample through the cystine/glutamate transporter. n EFFECT: invention provides the method for detecting oxidative stress in vivo in apoptotic cells by administering the visualising agent in a cystine/glutamate cell antiporter. n 14 cl, 10 dwg, 6 ex |