http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2522806-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2be5f1b02db59ff0cdd3a9d7cab7233 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-22 |
| filingDate | 2012-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2f7bc523544d6fd56a6ea1e83ed493b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18a2524f338133e86e93441d5ab4261a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7ba77f78df79f3ad1b2f2c6c1d176c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28d7b271b5fc8a2350ab51258034aab8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_732c8a097e8a04b83fc41aa5df4246c2 |
| publicationDate | 2014-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2522806-C1 |
| titleOfInvention | Improved method of purification of pravastatin |
| abstract | FIELD: biotechnology. n SUBSTANCE: purification of pravastatin is carried out from stereoisomer 6-epipravastatin. The culture liquid is centrifuged with a content of 6-epipravastatin 7% by weight of pravastatin for separation of mycelium. The native solution is prepared having pH 6.6. Purification of the native solution is carried out by filtration through a layer of basic alumina with pH 10, having activity corresponding to 8% of moisture. Alumina is taken in an amount of 25:1 relative to the amount of pravastatin in the native solution. Pravastatin is extracted by the organic solvent. Final purification of pravastatin is carried out through obtaining of intermediate ammonium salt using 25% aqueous ammonia solution and subsequent conversion to its sodium salt. n EFFECT: invention enables to carry out purification of pravastatin according to the pharmaceutical requirements to quality. n 2 cl, 2 ex |
| priorityDate | 2012-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.