| abstract |
FIELD: medicine. n SUBSTANCE: group of inventions relates to the field of medical diagnostics, immunology and oncology, in particular to novel oncomarkers and methods of diagnosing oncologic diseases. Claimed are novel antigens for carrying out immunoassay in order to identify autoantibodies, associated with malignant neoplasms, namely fragments of kringle-containing plasminogen. Also claimed is a method of identification of a diagnostic feature in case of oncologic diseases, consisting in identification of IgA, IgG, IgM type of autoantibodies to the following fragments of plasminogen: heavy chain (Glu-H), heavy chain (Lys-H), light chain (L), K1-4 (Tyr80-Ala440), K1-3 (Tyr80-Val338), K1-3 (Tyr80-Val354), K1-4 (Asn60-Pro447), K1-4 (Lys78-Pro447), K1-4 (Lys78-Pro446), K1-4 (Lys78-Lys468), K1-4.5 (Lys78-Arg530), K4-5 (Val355-Phe546), K1 (Tyr80-Glul64), K2-3 (Cysl65-Val338), K4 (Val354-Ala440), K5 (Ser441-Fhe546), K5 (Val442-Arg561), miniplasmin in a human blood plasma sample. n EFFECT: group of inventions is efficient in early diagnostics of oncologic diseases. n 5 cl, 2 dwg, 1 tbl, 5 ex |