| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to a compound selected from a group consisting of compounds presented by formula: n n n n In the above formula, R 1 represents S-Alk-R, wherein Alk represents methylene, C 2 -C 6 polymethylene bond or C 3 -C 6 alkenylene bond, R represents -N=C(NR 3 R 4 )(NR 5 R 6 ) or -NR 7 [(NR 3 R 4 )C=NR 5 ], or -N=C(R 8 )(NR 9 R 10 ), wherein R 3 -R 10 represents H, Alk, Ar or (CH 2 ) n Ar, wherein Ar represents an aryl group, and n represents an integer from 1 to 13, or R 3 and R 4 , or R 4 and R 5 , or R 5 and R 7 , or R 3 and R 7 , or R 9 and R 10 , or R 8 and R 9 together can represent -(CH 2 ) x -, wherein x represents an integer from 2 to 5, and R 2 is specified in a group consisting of hydroxyl, alkyl having from 1 to 7 carbon atoms, and substituted by alkyl hydroxyl having from 1 to 7 carbon atoms. n EFFECT: preparing new cyclosporine derivatives. n 5 cl, 2 ex |