http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2520222-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_54b91938b9c8bfc0ef66e5f17d26fee4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-12 |
| filingDate | 2009-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_028a1e0c53ae91ca1dbb122f3f68fac6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2edfea6c7280df9a62fc945e311d530 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b6082e78de42e74f9106acf11dba5f3 |
| publicationDate | 2014-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2520222-C2 |
| titleOfInvention | Buprenorphine analogues |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to buprenorphine analogues of formula , where R 1 is selected from -(C 1 -C 10 )alkyl, -(C 2 -C 12 )alkenyl, -(C 3 -C 12 )cycloalkyl, ((C 3 -C 12 )cycloalkyl)-(C 1 -C 6 )alkyl-; any of which is optionally substituted with 1 or 2 substitutes selected from OH and -(5-12-member)heterocycle, wherein at least one carbon atom is substituted with a nitrogen heteroatom; R 2 and R 8 each independently is hydrogen, -(C 1 -C 10 )alkyl, -(C 2 -C 12 )alkenyl, -(C 2 -C 12 )alkynyl, -(C 3 -C 12 )cycloalkyl, -(5-9-member)heteroaryl, where in the 5-9-member heteroaryl, at least one carbon atom is substituted with a nitrogen, oxygen or sulphur heteroatom, phenyl and naphthyl; any of which is optionally substituted with one or two substitutes selected from OH, halo, -C(halo) 3 , -(C 1 -C 6 )alkyl, phenyl, NH 2 , CN, OR 4 and COOR 7 ; at least one of R 2 or R 8 is not hydrogen; R 3a and R 3b are independently selected from hydrogen and -(C 1 -C 6 )alkyl; R 4 is selected from -(C 1 -C 6 )alkyl, -C(halo) 3 and phenyl; R 7 is hydrogen; X is selected from (C 1 -C 6 )alkoxy or OH; Z is (CH 2 ) m ; Y is (CH 2 ) n -CH or a direct bond, under the condition that when Y is a direct bond, R 8 is absent; m equals 1 and n equals 0. The invention also relates to a pharmaceutical composition which modifies opioid receptor function and is intended to treat pain, which contains compounds of formula I, a method of preparing said composition, a method of modulating an opioid receptor and a method of treating pain. n EFFECT: compounds of formula I as opioid receptor function modulators. n 37 cl, 11 dwg, 7 tbl, 6 ex |
| priorityDate | 2008-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 636.