| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to low-molecular inhibitors of N-terminus activation of androgen receptors of formula B: or pharmaceutically acceptable salts thereof, where: X denotes N; Y denotes O; R 1 denotes OJ, where J denotes a linear or branched, saturated C 1-10 alkyl; R 2 denotes a linear or branched, saturated, optionally substituted C 1-10 alkyl, where the optional substitute denotes one or more: F, Cl, Br and I; R 3 denotes H; R 4 denotes H, linear or branched, saturated C 1-4 alkyl, optionally substituted, where the optional substitute denotes one or more: F, Cl, Br and I; R 5 denotes a linear or branched, saturated C 1-10 alkyl, optionally substituted, where the optional substitute denotes one or more: F, Cl, Br and I; Z denotes Bu, Pr, Et or Me; denotes a double bond; and under the condition that the compound is not: . n EFFECT: compound exhibits inhibiting activity on AR, which allows use thereof to treat various diseases, including prostate cancer. n 26 cl, 9 dwg, 2 tbl, 6 ex |