http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2519641-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc977daeb01e7ddcd433cfa260e14ade |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2818 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 |
| filingDate | 2010-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb240ff915798ce82075dc73bae68f3b |
| publicationDate | 2014-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2519641-C2 |
| titleOfInvention | Method for preclinical testing of immunomodulatory agents |
| abstract | FIELD: medicine. n SUBSTANCE: invention refers to medicine, and describes a method for testing a planned or known immunomodulatory agent for T-cell activation which involves the stage of contacting a peripheral blood mononuclear cell (PBMC) culture with the pre-determined amount of the planned or known immunomodulatory agent in vitro and observing the T-cell activation in the PBMC culture using a readout system, when contacting the planned or known immunomodulatory agent, wherein the PBMC culture density at the stage of pre-culture makes at least 2×10 6 /ml, preferentially at least 5×10 6 /ml, more preferentially at least 10 7 /ml, or at least 4×10 5 /cm 2 , preferentially at least 10 6 /cm 2 , most preferentially at least 2×10 6 /cm 2 ; the PBMC pre-culture is cultured for at least 12 hours. n EFFECT: invention provides the improved agent for testing the immunomodulatory agents in vitro. n 10 cl, 16 dwg, 13 ex |
| priorityDate | 2009-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 248.