| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: there are offered: using an agent improving absorption and containing an ester of fatty hydroxy acid and polyethylene glycol 660 (particularly Solutol® HS15) as a part of a pharmaceutical composition as the agent improving absorption of the therapeutic agent through a mucous membrane, wherein the therapeutic agent has the value log P less than approximately 1 and (a) represents a peptide, a protein, a nucleic acid, an antigen or a vaccine; and/or (b) is other than a P-glycoprotein (P-Gp) substrate. The pharmaceutical composition of the above substances (versions), a method for preparing it and a method for administering, and using the ester of fatty hydroxy acid and polyethylene glycol 660 for preparing the above therapeutic agent are also presented. n EFFECT: higher insulin absorption from the declared agent vs absorption thereof from a formulation with PEG and PEG-hydroxystearic acid has been shown, with Solutol® HS15 having the slight effect on opening the tight contacts of epithelial cells. n 35 cl, 8 dwg, 9 ex |