| abstract |
FIELD: chemistry, pharmacology. n SUBSTANCE: group of inventions relates to insulin conjugate, possessing improved action duration and stability in vivo, obtained by covalent binding of insulin with Fc region of immunoglobulin via non-peptidyl polymer, as well as to composition of prolonged action, which contains it, and to method of their obtaining. n EFFECT: support of insulin activity in vivo at relatively high level and considerable increase of period of its serum half-life, with considerable increase of improvement of medication intake regimen in comparison with insulin therapy. n 21 cl, 8 ex, 6 dwg |