| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: there are described new compounds of general formula [I]: or their pharmacologically acceptable salts, wherein R 1 is C 1-6 alkyl; R 2 is C 1-6 alkoxy; m and n mean 1; W means N; the ring A represents fragments of formula , or that can be substituted; X 1 is a single bond, C 1-6 alkylene group or -C(O)NR 3 -, wherein R 3 is hydrogen, C 1-6 alkyl or phenyl; and the ring B represents fragments of formula [5]-[11]: that can be substituted, and a pharmaceutical composition containing them. n EFFECT: new compounds possess activity inhibiting the amyloid beta production, and are effective as a therapeutic agent for treating an Aβ-caused disease, such as Alzheimer disease or Down syndrome. n 10 cl, 48 tbl, 399 ex |