| abstract |
FIELD: chemistry. n SUBSTANCE: claimed invention relates to field of organic chemistry, namely to novel compound of formula (I), where Y and Z, each independently, are selected from group, consisting of: a) phenyl, if necessary substituted with 1 or 2 R 6 ; b) pyridine, imidazole, thiazole, furan, triazole, quinoline or imidazopyridine, if necessary substituted with 1 R 6 ; and c) substituent, independently selected from group, consisting of hydrogen, C 1 -C 6 alkyl or pyperidine; R 1 , R 2 and R 3 , each independently selected from group, consisting of hydrogen and halogen; A and B is each independently selected from hydrogen, OH and C 1 -C 6 alkyl; R A and R B are independently selected from group, consisting of hydrogen, C 1 -C 6 alkyl and C 3 -C 8 cycloalkyl; or R A and R B together with atom, to which they are attached, form 4-6-membered heterocycle, if necessary having additionally one heteroatom or functional heterogrpoup, selected from group, consisting of -O-, -NH, -N(C 1 -C 6 -alkyl)- and -NCO(C 1 -C 6 -alkyl)-, and 6-membered heterocycle can be additionally substituted with one or two C 1 -C 6 -alkyl groups; R 4 and R 5 , each stands for hydrogen; and each R 6 is selected from Br, Cl, F, I, C 1 -C 6 -alkyl, pyrrolidine, if necessary substituted with one C 1 -C 6 -alkyl, C 1 -C 6 alkoxy, halogen-C 1 -C 6 alkyl, hydroxyl-C 1 -C 6 alkylene, -(NR A R B )C 1 -C 6 alkylene and (NR A R B )carbonyl; or to its individual isomer, stereoisomer or enantiomer, or their mixture, if necessary pharmaceutically acceptable salt. Invention also relates to compound of formula (II), particular compounds of formula (I) and (II), pharmaceutical composition and industrial product based on compound of formula (I) and (II), method of treating said pathological conditions, method of obtaining formula (I) compound and to intermediate compound of formula 3. n EFFECT: novel compounds, useful as inhibitors of poly(ADP-ribose)polymerase, are obtained. n 50 cl, 1 tbl, 159 ex |