http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2504389-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_072820ba161b2511a33e54dbd742ccb8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-74 |
| filingDate | 2012-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c9f6a3c297fa7981bb49648dcd39e62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_850de4c79e27b84ac9d22e96c215ff28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_248f9f704044b79722522bbe7bf80bd7 |
| publicationDate | 2014-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2504389-C2 |
| titleOfInvention | METHOD FOR PORE FORMATION IN HEPATOCYTE MEMBRANES BY Bacillus cereus HEMOLYSIN II PROCESSING |
| abstract | FIELD: medicine. n SUBSTANCE: invention refers to biotechnology and represents a method involving Bacillus cereus hemolysin (HlyII) hemolysin processing of primary membrane hepatocyte and determining the membrane permeability after HlyII processing. Substance of the presented invention consists in the fact that the action of the HlyII preparation on the cell membranes provides the more effective transport of various low-molecular compounds through the cell membranes. The object in view is to form nanometric pores in the hepatocyte membranes ensured by the action of the low concentration of the purified HlyII preparations on the primary hepatocytes. An increase of the hepatocyte membrane permeability after the HlyII preparation processing is determined by microspectral analysis of low-molecular fluorescent dyes. As observed, the increased permeability of the above dyes into the hepatocyte permeability characterises higher permeability of the processed hepatocyte membranes. n EFFECT: invention provides the effective and reliable method for fast and stable increase of the primary hepatocyte membranes for transport of the low-molecular compounds therein. n 1 dwg |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2741645-C2 |
| priorityDate | 2012-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 102.