| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: present invention refers to a compound of general formula (I): wherein m and n independently represent 0 or 1; G and E represent oxygen, R 1 and R 2 together with a carbon atom whereto attached form a heterocycle including one or two heteroatoms specified in oxygen, sulphur, -S(O)-, -S(O) 2 -, -N=, -N(R 5 )-; one or more carbon atoms in the above heterocycle are optionally substituted by one or more identical or different substitutes specified among the substitutes R 4 ; R 3 represents alkoxy or halogenoxy; R 4 represents hydrogen, alkyl or halogen; R 5 represents hydrogen, alkyl carbonyl, alkoxy carbonyl or alkyl sulphonyl; X represents a bond, -CH 2 - or -NH-; A represents phenyl, pyridyl, pyrazynyl or quinolyl optionally substituted by one or more identical or different substitutes specified among the substitutes R 4 ; or pharmaceutically acceptable salts, hydrates, N-oxides or salvates thereof. n EFFECT: invention also refers to the pharmaceutical composition of the above compounds as the phosphodiesterase PDE4 inhibitor for treating, eg skin diseases. n 19 cl, 2 tbl, 32 ex |