http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2492170-C9
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f96a6311b62a38344a5c64a4bc55a016 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8efd953b28de32752a94769cf6e9023 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate | 2008-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66a9aa4e572c4f1da8e709445ad88d40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a58cead6be5e68eeb253156a54090b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ca74f6a9f8b5200607d14df02757c4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42896aaca591bdcdc23c9516338a7717 |
| publicationDate | 2013-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2492170-C9 |
| titleOfInvention | Imidazo[1,2-a]pyridine derivatives and their application as positive allosteric modulators of mglur2 receptors |
| abstract | FIELD: medicine, pharmaceutics.SUBSTANCE: claimed invention relates to novel imidazo[1,2-a]pyridine derivatives of general formula(I) or to its stereochemical isomeric forms, or to its pharmaceutically acceptable salts, where Rrepresents Calkyl; Ccycloalkyl; trifluoromethyl; Calkyl, substituted with trifluoromethyl, Ccycloalkyl, phenyl; phenyl, substituted with 2 substituents, selected from group, consisting of halogeno; Rrepresents cyano, halogeno or Calkyl; Rrepresents radical of formula(a), or(b), or(d); Rrepresents hydroxyCcycloalkyl; pyridinyl, substituted with one Calkyl group; pyrimidinyl; pyrimidinyl, substituted with two Calkyl groups; phenyl; phenyl, substituted with 1 or 2 substituents, selected from group, consisting of halogeno, hydroxyCalkyl, mono- or polyhalogenoCalkyl, Calkyloxy and monohalogeno- Calkyloxy; Rrepresents hydrogen, fluoro, hydroxyl or monopholinyl; X represents C or N, with Rrepresenting electron pair on N; or R-X-Rrepresents radical of formula(i), or(j), or(k); n equals 0 or 1' q equals 1 or 2; Rrepresents Calkyl; Ccycloalkyl; hydroxyCalkyl; (Ccycloalkyl)Calkyl; phenyl; or phenyl, or pyridinyl, substituted with one substituent, selected from group, consisting of halogeno, Calkyl and (CH)-COH, where m equals 0; or Rrepresents cyclic radical of formula(l); where Rrepresents hydrogen, p equals 2; Z represents O or CR(OH), where Rrepresents hydrogen or Calkyl; Rrepresents hydrogen or halogeno; Y represents covalent bond, O, NH, S, C(OH)(CH), -CH-O-, -O-CH-, CHF or CF; or R-Y represents morpholinyl, pyrrolidinyl or piperidinyl, possibly substituted with hydroxyl or hydroxyCalkyl; and A represents O or NH. Invention also relates to pharmaceutical composition based on formula (I), its application and method of treatment or prevention of central nervous system disorders.EFFECT: novel imidazo[1,2-a]pyridine derivatives, which possess activity of positive allosteric mGluR2 modulator are obtained.21 cl, 3 tbl, 22 ex |
| priorityDate | 2007-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.