http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2490252-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff346a4b8595551f1fdd6153af5a1907 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-313 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-30 |
| filingDate | 2012-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6173c1c0d038997fad62d0789f8396a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_162e4f04dace7e81239bb5941ff03714 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1d99558b5f6c4493a67efe87e25c38f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6edc0060ea5501368e6b9aa6714fb0a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e6094b738d681330b1c904d342a5066 |
| publicationDate | 2013-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2490252-C1 |
| titleOfInvention | Method of obtaining ethyl ester of 2-methyl-3-oxo-4-(2,6-difluorophenyl)pentanoic acid |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to field of synthesis of 1,3-dicarbonyl compounds, namely to method of obtaining ethyl ester of 2-methyl-3-oxo-4-(2,6-difluorophenyl)pentanoic acid, which is applied as precursor of anti-HIV-1 active derivatives of 2-amino-6-[1-(2,6-difluorophenyl)ethyl]-5-methylpyrimidin-4(3H)-one. method of obtaining formula compound is realised in medium of organic solvent with application of 2-(2,6-difluorophenyl)propionyl chloride as acylating agent, with further processing of reaction mass with water solution of hydrochloric acid and separation of target product. Di(chloromagnesium) salt of ethyl ester of 2-methyl-3,3-dihydroxyakrylic acid is subjected to acylation, and as solvent used is absolute di-isopropyl ester, with molar ratio of 2-(2,6-difluorophenyl)propionyl chloride: di(chloromagnesium) salt of ethyl ester of 2-methyl-3,3-dihydroxyakrylic acid being equal 1:1.6-2.2. n EFFECT: increased manufacturability of synthesis as well as increased output of product with high purity degree. n 3 ex |
| priorityDate | 2012-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 98.