abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: there are described fumaryl diketopiperazin (FDKP) formulations and microparticles with the particular amount of trans-isomer making approximately 45% to approximately 65%. The FDKP microparticles can contain a drug such as endocrine hormone including a peptide, including insulin, glucagon, parathyroid hormone, and can be used to prepare a powder for pulmonary drug delivery. n EFFECT: fumaryl diketopiperazin (FDKP) microparticles with the above amount of trans-isomer show the improved aerodynamic properties. n 27 cl, 6 dwg, 6 tbl, 3 ex |