http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2489176-C1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_46f882b37b5e9329093a0425e9292ffb |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-722 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-726 |
filingDate | 2012-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2013-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e32c251976e7c57233172d3ac64a8d3c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2de4adca74097d89c7b1076d120099e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e9f93b4a6f00f2b1b068c2ff002cd40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_065983443861021fdf8c0b9f5fc81289 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76038ce4024b4b1d242ef10a3400e56d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b33a42d2d7bc96136aa7586a1ded97c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7c008fda11d11224f08a4e233329840 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17a56acf4f9617538925455e0bc49e49 |
publicationDate | 2013-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | RU-2489176-C1 |
titleOfInvention | Method of spinal tissue engineering following anatomical rupture |
abstract | FIELD: medicine. n SUBSTANCE: invention refers to medicine, namely to neurosurgery and transplantology, cell technology and bioengineering, and may be used for reconstruction of the anatomically ruptured spinal cord. That is ensured by implanting cells being parts of a collagen-chitosan matrix containing either a conditioned combined DME medium consisting of two media prepared by cell culture of rat embryo's brain tissue and mouse embryo's stem cells, or a conditioned DMA medium prepared by cell culture of mouse embryo's stem cells only in the presence of neuronal N2 and B27 additives and retinoic acid, into the spinal diastasis. Immediately before the implantation, the cell matrix is placed in a synthetic DME/F12 medium. Besides, the collagen-chitosan matrix contains the complex of polysaccharides with nano-microstructured components including chitosan ascorbate of molecular weight 695 kDa and a degree of deacetylation of 98% with ascorbic acid 1.8 g, chondroitin sulphuric acid 20 mg, hyaluronic acid 10 mg and heparin 5 mg or salt derivatives thereof per 1 g of dry chitosan. n EFFECT: method enables the adequate restoration of the morphological and functional spinal integrity following a partial or complete anatomical rupture. n 2 cl, 5 ex, 13 dwg |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2644278-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2803525-C1 |
priorityDate | 2012-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 936.