| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: application describes new pharmaceutical compositions of (2R,3R,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-4-fluor-2-isobutylryloxymethyl-4-methyl-tetrahydrofurane-3-yl ester of isooleic acid and hydroxypropyl cellulose. The composition contains 50 to 95 wt % of the above active agent, 1 to 4 wt % of hydroxypropyl cellulose and at least one excipient in the amount up to 49 wt %. n EFFECT: compositions according to the invention provide high bulk density, low granule size, more applicable for better compactibility, flowability and improved solubility profiles. n 21 cl, 8 dwg, 11 tbl, 20 ex |