| abstract |
FIELD: chemistry. n SUBSTANCE: present invention relates to organic chemistry and specifically to novel 2,5-dioxo-imidazolidine derivatives of general formula lb , or pharmaceutically acceptable salts and solvates thereof, or solvates of pharmaceutically acceptable salts, where X denotes O; R 1 is H; or R 1 is selected from C 1 -C 6 alkyl and C 1 -C 6 alkynyl, where the alkyl can optionally be substituted with a cyano group; R 2a is selected from H, P(O)(OH) 2 and C(O)(CH 2 ) n1 C(O)OH; or R 2a is selected from -C(O)-C 1 -C 6 alkyl, which is substituted with amino; n1 equals 1 or 2; each R 2 and R c is independently selected from H and C 1 -C 6 alkyl; R 3a is H, a halogen atom or cyano; each R 3b is independently a halogen atom or cyano; or each R 3b is independently C 1 -C 6 alkyl, optionally substituted with three halogen atoms; each R 4a and R 4b is independently H or a halogen atom; or each R 4a and R 4b is selected from C 1 -C 6 alkyl, and C 1 -C 6 alkoxy, where the alkyl is substituted with three halogen atoms; R 4c is a halogen atom or cyano; and ml equals 0 or 1. The invention also relates to a pharmaceutical composition based on a compound of formula lb and use thereof. n EFFECT: obtaining novel 2,5-dioxo-imidazolidine derivative which modulate androgen receptor activity. n 20 cl, 5 tbl, 31 ex |