| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to pharmaceutics, more specifically to a film base with dispersed fine particles of one or more sugars or sugar alcohols, and also refers to a film preparation containing the base and medicinal agent. The method for preparing the base consists in dissolving an edible polymer soluble in water or an organic solvent in an organic solvent of a solubility parameter of 9.7 (cal/cm 3 ) 1/2 or higher, and dispersing one or two or more compounds specified in a group consisting of sugars, including mono- to hexasaccharides, and sugar alcohols thereof having an average particle size of 0.1 mcm to 60 mcm, and insoluble in an organic solvent. n EFFECT: invention may create the film oral base and preparation having a fast profile of oral solubility and adequate film strength, and provide a reduced oral adhesiveness of the water-soluble polymer, and improved feeling if held in fingers. n 12 cl, 26 ex, 12 tbl, 5 dwg |