| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to pharmaceutical industry and represents a thermoreversible, thermoplastic pharmaceutical composition comprising: (a) a biologically active botulinum toxin and (b) a thermoplastic poloxamer wherein poloxamer stabilises botulinum toxin so that botulinum toxin keeps biological activity with botulinum toxin release from the pharmaceutical compositions in vivo, wherein the pharmaceutical composition can be prepared with no substances contained in blood, such as albumin and therefore without any infectious substances of blood components, such as prion. n EFFECT: invention provides high stability and high percentage of the toxin activity recovery. n 18 cl, 6 ex |